01720nas a2200265   4500000000100000008004100001260002700042653001900069653002600088653002200114653001300136653002200149653002300171100001600194700001500210700001500225700001600240700001700256700001200273700001100285245008400296490000700380520105300387022001401440       2025                            d  bOur Dermatology Online10aHansen disease10aMycobacterium leprae 10aDelayed Diagnosis10aSymptoms10amedical protocols10abacterial cultures1 aKhallouki M1 aBendaoud L1 aSerghini S1 aHoubayeli M1 aAboudourib M1 aHocar O1 aAmal S00aRare multisystemic complications with delayed diagnosis in two cases of leprosy0 v163 a<p>Leprosy is a multisystem granulomatous disease caused by infection with Mycobacterium leprae. Herein, we report two cases of delayed diagnosis of leprosy with multisystemic involvement. A 48-year-old male patient presented with leonine facies, generalized infiltrated plaques, paresthesias, amyotrophy of the dorsal muscles of the hands, and hypoesthesia of the lower limbs evolving for three years. A 63-year-old male patient presented with infiltrated plaques of the face, hypoesthesia of the feet, acro-osteolysis of the fingers and toes, and paresthesias, all of an undetermined chronic course. The two patients were diagnosed with multibacillary leprosy on the basis of the positive bacteriological sampling of the ear lobe. The patients had multisystem involvement: neurological, bone, ocular, and nasal. The patients received the recommended treatment regimen based on dapsone, clofazimine, and rifampicin. Physicians should be vigilant in screening and treating new active cases of leprosy even in the post-leprosy elimination era.</p>
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