02401nas a2200301   4500000000100000008004100001260001200042653001900054653001200073653002300085653002300108653002100131653001900152100001500171700001600186700001400202700001800216700001700234700001500251700001700266700001400283245011000297856006800407300000900475490000700484520159400491022001402085       2025                            d  bMDPI AG10aHansen disease10aleprosy10aNeglected Diseases10aEcological studies10aSpatial analysis10aPublic health 1 aBarbosa CC1 aBezerra GSN1 aXavier AT1 aOliveira ALSD1 aMedeiros MSD1 aBonfim CVD1 aMedeiros ZMD1 aSouza WVD00aAnalysis of the Spatial Distribution of New Cases of Leprosy in the State of Pernambuco, Northeast Brazil  uhttps://www.mdpi.com/2414-6366/10/12/327/pdf?version=1763723916  a1-180 v103 a<jats:p>Spatial analysis of leprosy case distribution serves as a critical tool for identifying priority areas for intervention, particularly in settings with marked epidemiological heterogeneity. This study aimed to analyze the spatial distribution of new leprosy cases in Pernambuco, Brazil, 2000–2024. This is an ecological study with the municipalities of residence as the units of analysis. The data was extracted from the Notifiable Diseases Information System. The average incidence rates were calculated: general, in children under 15 years of age and with grade 2 physical disability at diagnosis, for four five-year periods. Bayesian smoothing and Moran’s global and local autocorrelation statistics were applied. The average rates of overall detection were 29.0/100,000 inhabitants per year (very high); in children under 15 years of age, 10.7/100,000 inhabitants per year (hyperendemic); and grade 2 physical disability, 1.6/100,000 inhabitants per year (low). Spatial analysis showed significant spatial heterogeneity, with clusters of high overall detection rates of leprosy cases, high detection rates among children under 15, and high rates of grade 2 physical disability at diagnosis, mainly in macro-regions I and IV. There is circulation of Mycobacterium leprae across all macro-regions of the state, with evidence of active transmission foci in macro-region III. Therefore, municipalities with a priority for intervention are concentrated in macro-regions I and IV, highlighting the need to strengthen leprosy surveillance and control actions in the state.</jats:p>  a2414-6366