01307nas a2200337 4500000000100000008004100001260001300042653001000055653001100065653001600076653001100092653001100103653002100114653001200135653000900147653002500156653001600181653002900197653002500226653001400251653001600265653001000281100001600291700001400307700001500321245004100336300001000377490000700387520056100394022001400955 1985 d c1985 Dec10aAdult10aBiopsy10aEndothelium10aFemale10aHumans10aInclusion Bodies10aleprosy10aMale10aMicroscopy, Electron10aMiddle Aged10aMuscle, Smooth, Vascular10aMycobacterium leprae10aPhlebitis10aPinocytosis10aVeins1 aMukherjee A1 aMisra R S1 aSharma A K00aUltrastructure of leprous phlebitis. a571-60 v533 a

An ultrastructural study on vein biopsies from six lepromatous leprosy patients was carried out. The results showed that a) the lumen-lining bacillated cells were endothelial in origin due to the presence of specific Weibel-Palade endothelial cell granules; b) endothelial cells released Mycobacterium leprae into the lumen by exophagocytosis; c) M. leprae were able to grow and multiply in the endothelial and smooth muscle cells; and d) smooth muscle cells did not show any evidence of reaction due to the presence of M. leprae in their cytoplasm.

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