01905nas a2200265   4500000000100000008004100001260001200042653003000054653002600084653001900110653002400129653001200153100001500165700001300180700001500193700001100208700001600219700001300235245009700248856008500345300000800430490000900438520117800447022001401625       2025                            d  c10/202510aErythema Nodosum Leprosum10aType 2 lepra reaction10aimmune complex10alepromatous leprosy10aleprosy1 aAlhariri B1 aIllahi M1 aElshaikh N1 aOmer R1 aAlQahtani N1 aSharif M00aRevealing Erythema Nodosum Leprosum in a Leprosy Patient: A Case of Treatment Noncompliance.  uhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/crdi/1071013?download=true  a1-50 v20253 a<p>Lepra reactions (LR) are acute inflammatory conditions with immune mediators that are highly morbid. Patients with the lepromatous end of the leprosy spectrum (BL-LL) are the only ones who develop Type-2 LR. 90% of the time, it happens during or right after treatment, usually within 2 years. The emergence of Erythema Nodosum Leprosum (ENL) suggests a paradoxical immune reaction and hypersensitivity to leprosy bacteria that results in painful erythematous nodules and systemic symptoms. Here, we present a case of Type 2 LR in a 41-year-old Indian man diagnosed with lepromatous leprosy 2 years ago. He was treated with MDT regime for 12 months and was compliant with treatment till 1 month before presenting with fever, cough, red eyes, and painful erythematous nodules involving his trunk and extremities. This case underscores the severe systemic inflammatory response that can be triggered by noncompliance with MDT, mimicking sepsis and requiring prompt recognition and management. Early recognition of ENL and appropriate management are essential to alleviate symptoms and prevent serious complications that may result from this serious condition.</p>
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