01573nas a2200241   4500000000100000008004100001260003400042653001200076653002000088653001200108653001600120100001300136700001300149700001600162700001200178700001200190700001500202245006300217856026000280300000800540520076900548022001401317       2025                            d  bOxford University Press (OUP)10aLeprosy10aHistoid leprosy10aRelapse10aCase report1 aMathur M1 aPaudel S1 aBhattarai N1 aRegmi S1 aKarki S1 aShrestha S00aAn unusual presentation in relapse case of histoid leprosy  uhttps://watermark02.silverchair.com/vzaf067.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA28wggNrBgkqhkiG9w0BBwagggNcMIIDWAIBADCCA1EGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM3R3GmvKZyyzrPvkFAgEQgIIDIpnSvG0pHIyHa_E2dI3Egjh9fQzFZxUaL8naV5z8q6rnp  a1-33 a<p>Histoid leprosy (HL) is a very rare and highly infectious variant of lepromatous leprosy, presenting as skin-coloured, succulent nodules and plaques on apparently healthy skin. It is histologically characterized by a dense bundle of histiocytes arranged in storiform manner. Usually, it occurs in patients with leprosy who relapse after dapsone monotherapy or inadequate antileprotic treatment; it can even arise de novo. We present a case of umbilicated presentation in a patient with a case of relapse HL, even after adequate treatment with multibacillary multidrug therapy for 12 months. Although rare, the higher load of lepra bacilli in these cases makes it a matter of concern, and challenging for leprologists to make early diagnosis and treatment.</p>
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