01300nas a2200289   4500000000100000008004100001260001300042653001000055653001500065653001500080653001100095653001100106653001200117653002600129653001600155653000900171653001600180653002400196653001500220100001600235700001500251245013900266300000900405490000700414520057500421022001400996       1986                            d  c1986 Mar10aAdult10aCyclic AMP10aCyclic GMP10aFemale10aHumans10aleprosy10aLymphocyte Activation10aLymphocytes10aMale10aMiddle Aged10aPhytohemagglutinins10aTuberculin1 aBalybin E S1 aNaumov V Z00aDependence of proliferative activity of lymphocytes on basal levels of lymphocytic cyclic nucleotides in lepromatous leprosy patients.  a52-60 v543 a<p>The correlation between the lymphocyte blast transformation test and the basal levels of cyclic nucleotides (cAMP and cGMP) in lymphocytes was studied in 30 patients with lepromatous leprosy and 14 healthy persons. Cells in cultures of whole blood were stimulated with PPD and PHA. As compared to healthy persons, leprosy patients showed inversion of the role of cGMP basal levels in proliferative activity of lymphocytes in a response to PPD. The data obtained give rise to a hypothesis which might explain the low effectiveness of immune stimulators in leprosy.</p>  a0148-916X