01847nas a2200277   4500000000100000008004100001260001200042653002100054653002500075653001600100653002800116653002400144100001200168700001400180700001500194700001600209700001600225700001500241700001700256245008900273856007900362300000800441490000900449520109700458022001401555       2025                            d  c01/202510aHansen's disease10aMycobacterium leprae10aCase report10agranulomatous disorders10alepromatous leprosy1 aOsman M1 aAlharby T1 aAlhabeeb Y1 aElshenawy A1 aAlreshidi H1 aAlhayeti S1 aAlshammari A00aUncommon Presentation of Lepromatous Leprosy in a Nonendemic Setting: A Case Report.  uhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12449093/pdf/CRIM2025-8232445.pdf  a1-50 v20253 a<p>Leprosy, caused by , remains a significant public health concern in certain endemic regions, but it is rarely encountered in nonendemic areas, posing diagnostic challenges. This case report discusses an unusual presentation of lepromatous leprosy in a patient residing in Saudi Arabia with no history of travel to endemic regions. The patient's clinical features were atypical, lacking the classic neurological involvement and sensation loss commonly associated with leprosy. Definitive diagnosis was achieved through histopathological examination revealing diffuse histiocytic infiltrates, a grenz zone, and acid-fast bacilli confirmed by modified Ziehl-Neelsen staining. The patient responded well to multidrug therapy according to WHO guidelines. This case highlights the importance of maintaining high clinical suspicion, utilizing appropriate diagnostic techniques, and understanding the epidemiological complexities of leprosy in low-prevalence settings. Strengthening awareness and surveillance is essential to prevent underdiagnosis and curb transmission in nonendemic regions.</p>  a1687-9627