02540nas a2200229   4500000000100000008004100001260004600042653002900088653002100117653001200138100001400150700001500164700001500179700001300194700001500207245010500222856013300327300001200460490000700472520181700479022001402296       2025                            d  bOvid Technologies (Wolters Kluwer Health)10ahigh density lipoprotein10aInterferon-gamma10aLeprosy1 aHassan AR1 aEl Sary AY1 aMohamed SH1 aHosnay R1 aMohamad NE00aHigh-density lipoprotein levels and its correlation with Interferon-gamma levels in leprosy patients  uhttps://journals.lww.com/ejdv/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=01745968-202509000-00008  a293-3000 v453 a<p><strong>Background</strong></p>

<p>Mycobacterium lepra infection causes leprosy. Primarily affecting the skin and peripheral nerves, it is a persistent viral illness. Peripheral nerve damage can cause severe impairment and disability. The type of lipoproteins known as high-density lipoproteins (HDL) is distinguished by its capacity to return cholesterol from peripheral tissues to the liver. Their anti-inflammatory and antioxidant properties play a major part in their ability to prevent diseases. A pleiotropic molecule, interferon-gamma (IFN-γ) has mechanisms that are linked to antiproliferative, pro-apoptotic, and anticancer effects. Due to its ability to maintain both CD4+ and CD8+ cell activity and regulate a variety of protective functions, this effector cytokine is frequently regarded as a significant effector of immunity.</p>

<p><strong>Aim</strong></p>

<p>The current study aimed to evaluate HDL levels in sera of leprotic patients and assess its correlation with IFN-γ levels. Patients and methods This study included 31 leprotic patients and 30 healthy subjects as a control. Serum HDL is estimated by enzymatic methods using spectrophotometric assay kits while serum IFN-γ is estimated using commercially available enzyme-linked immunosorbent assay (ELISA).</p>

<p><strong>Results</strong></p>

<p>There was no statistically significant difference between the two studied groups regarding HDL. There was a higher statistically significant difference between the two studied groups regarding IFN-γ with higher levels in the cases group. There was no significant correlation between both HDL and IFN-γ and age and duration.</p>

<p><strong>Conclusion</strong></p>

<p>There is no correlation between serum levels of HDL and levels of IFN-γ in leprosy patients.</p>
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