01886nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653001200080653001100092653001100103653001200114653000900126653001600135653001800151653002200169653003900191653001600230100001500246700001700261700001700278700001300295700001700308245012700325300001000452490000700462520107700469022001401546       1987                            d  c1987 Mar10aAdolescent10aAdult10aDapsone10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aMotor Neurons10aNeural Conduction10aPeripheral Nervous System Diseases10aUlnar nerve1 aSébille A1 aCordoliani G1 aRaffalli M J1 aNebout M1 aChevallard A00aDapsone-induced neuropathy compounds Hansen's disease nerve damage: an electrophysiological study in tuberculoid patients.  a16-220 v553 a<p>In 17 previous cases of dermatological disorders, an axonal motor neuropathy was described as a dapsone (DDS) therapy side effect. In this study, we attempted to assess DDS-induced neuropathy in the ulnar and popliteal nerves of 39 tuberculoid Hansen's disease patients using electrophysiological recordings at the time of DDS withdrawal, owing to dermatological improvement, and 4 months after. Distal motor latencies, conduction velocities at forearm and leg and above the epicondyle and the neck of the fibula were improved at a highly significant level. Twenty-five percent of the patients presented abnormal values (outside of the 95% confidence interval) at the first recording session compared to those at the second session. By contrast, parameters exploring the degree of innervation of distal muscles showed a progressive denervation. These results lead to an impairment of Hansen's disease neuropathy during DDS therapy affecting the motor conduction velocities of one quarter of the patients, and are discussed in terms of physiopathological mechanisms.</p>  a0148-916X