01337nas a2200289   4500000000100000008004100001260001300042653001600055653001100071653002100082653001800103653001200121653002600133653002500159653001500184653003000199100001300229700001300242700001300255700001900268700001500287245013000302300001100432490000700443520058300450022001401033       1987                            d  c1987 Dec10aBCG Vaccine10aHumans10aImmune Tolerance10aImmunotherapy10aleprosy10aLymphocyte Activation10aMycobacterium leprae10aSkin Tests10aT-Lymphocytes, Regulatory1 aRada E M1 aConvit J1 aUlrich M1 aGallinotto M E1 aAranzazu N00aImmunosuppression and cellular immunity reactions in leprosy patients treated with a mixture of Mycobacterium leprae and BCG.  a646-500 v553 a<p>Suppressor reactivity was studied in a group of leprosy patients before and after immunotherapy with a mixture of Mycobacterium leprae and BCG. The treatment increases the responses in lymphocyte transformation tests to levels which are comparable to those observed in BT-TT patients and reduces suppressor activity. The soluble extract of M. leprae appears to be more sensitive than purified intact bacilli in the lymphocyte transformation tests, but this preparation did not induce suppressor reactivity with the regularity observed when using a Dharmendra preparation.</p>  a0148-916X