02233nas a2200193   4500000000100000008004100001260003400042653002800076653002500104100001200129700001100141700001400152700001200166700001200178245008600190856011400276520162400390022002502014       2025                            d  bOxford University Press (OUP)10aLeprosy, Paucibacillary10aErythematous macules1 aBaraz S1 aBaba R1 aAmraoui M1 aFrikh R1 aHjira N00aAn Atypical Presentation of Erythematous Macules Revealing Paucibacillary Leprosy  uhttps://academic.oup.com/ced/advance-article-abstract/doi/10.1093/ced/llaf363/8220666?redirectedFrom=fulltext3 a<p>Leprosy, caused by Mycobacterium leprae, remains a significant health concern in certain endemic regions despite global elimination efforts. This case describes a 53-year-old Moroccan woman presenting with a one-year history of asymptomatic erythematous macules associated with sensory deficits. Initial diagnoses included common dermatological conditions, leading to delays in definitive treatment. A detailed clinical examination revealed hallmark sensory loss in the lesions, with dermoscopy and histopathology supporting a diagnosis of paucibacillary leprosy. While bacilloscopic findings were negative, histological analysis demonstrated lymphocytic infiltration around nerve fibers, consistent with leprosy criteria. The patient was successfully managed with multidrug therapy (MDT) and educational reinforcement to promote adherence. Additionally, chemoprophylaxis with single-dose rifampicin was administered to household contacts, as recommended by the OMS. This report underscores the diagnostic challenges in paucibacillary leprosy, where overlapping clinical features may mimic other dermatoses. It highlights the crucial roles of histopathology, dermoscopy, and systematic neurological evaluations in confirming diagnoses, especially in resource-limited settings. Early diagnosis, effective treatment, and preventive strategies, including chemoprophylaxis, remain essential to reducing transmission and minimizing stigma in leprosy-endemic regions. The case emphasizes the continued vigilance required of dermatologists to recognize rare presentations and contribute to global eradication efforts.</p>
  a0307-6938, 1365-2230