01924nas a2200289   4500000000100000008004100001260004400042653002800086653002700114653004400141100000900185700001000194700001200204700001000216700000900226700001200235700001000247700000900257700001100266700001200277700000900289245009700298856005500395490000700450520116300457022001401620       2025                            d  bSpringer Science and Business Media LLC10aLeprosy, Multibacillary10aperipheral blood cells10aA single-cell V(D)J sequencing  dataset1 aLi Z1 aJia J1 aZhang Q1 aTan H1 aYu X1 aZhang C1 aYin L1 aDu Y1 aPeng C1 aKuang Y1 aLi Y00aA single-cell V(D)J sequencing dataset of peripheral blood cells in  multibacillary leprosy  uhttps://www.nature.com/articles/s41597-025-05616-20 v123 a<p>Leprosy is a chronic infectious disease caused by Mycobacterium leprae (Mlep), and is classifed as a tropical disease by the WHO. While prior research has documented the various phenotypes and functions of T cells and B cells in Mlep infection, the specifc clonotypes of T cells and B cells that are essential for understanding the progression of multibacillary leprosy have not been reported. Here, we established a single-cell V(D)J sequencing dataset including 5 multibacillary leprosy patients (MBs) and 5 healthy individuals (HCs), aiming to generate comprehensive profles of T-cell receptors and B-cell receptors present in the peripheral blood. This study suggested that Mlep infection has distinct selective efects on peripheral immune repertoires and that these biased immune repertoires observed in MBs have potential as biomarkers. This dataset provides very comprehensive and valuable data on the peripheral blood immune repertoire of multibacillary leprosy patients. It holds considerable importance in the clinical monitoring and management of Mlep infections, ultimately contributing to the WHO goal “Towards Zero Leprosy” by 2030</p>
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