01505nas a2200229   4500000000100000008004100001260001200042653002500054653001500079653001200094653003200106653002700138100001400165700001400179700001500193700001400208700001500222245011400237856004600351520086400397022001401261       2025                            d  c07/202510aLucio’s phenomenon10aVasculitis10aLeprosy10aantiphospholipid  antibody,10arheumatologic  disease1 aHidayat R1 aDamanik J1 aAraminta A1 aMarissa M1 aMaharani M00aLucio phenomenon and antiphospholipid antibodies in leprosy mimicking rheumatologic disorders: a case report.  uhttps://pubmed.ncbi.nlm.nih.gov/40698393/3 a<p>Hansen's disease, also known as leprosy, is often termed "the great imitator" due to its diverse clinical presentations that can mimic various rheumatologic disorders. We present the case of a 34-year-old female who developed extensive purpuric rashes, initially raising suspicion of vasculitis. Laboratory investigations revealed triple-positive antiphospholipid antibodies. However, skin smears and histopathological examination confirmed a diagnosis of diffuse lepromatous leprosy complicated by Lucio phenomenon. This case highlights the importance of considering infectious etiologies, such as leprosy, in the differential diagnosis of vasculitis and rheumatologic diseases. Given the overlapping clinical features, a comprehensive patient history and careful interpretation of autoantibody tests are essential for achieving an accurate diagnosis.</p>  a0048-7449