01114nas a2200253   4500000000100000008004100001260000900042653001200051653001500063653001200078653000900090653001200099653000900111653001600120653001600136653001800152653001900170100001500189245012500204300001200329490000700341520049800348022001400846       1986                            d  c198610aAnimals10aColchicine10aDapsone10aMale10aMitosis10aOvum10aSea Urchins10aSpermatozoa10aSulfanilamide10aSulfanilamides1 aMedina H S00aThe effect of diamino diphenyl sulfone on the embryonic development of eggs from the sea urchin (Lytechinus variegatus).  a295-3060 v833 a<p>Diamino diphenyl sulfone (DDS), a chemotherapeutic compound used in the treatment of leprosy, was studied with regard to its effects on the embryonic development of eggs from the sea urchin Lytechinus variegatus. DDS disturbs the normal development of fertilized eggs by interfering with the mitotic apparatus and producing spheroid-shaped bodies shown to be aster-like bodies by staining techniques. A typical colchicine effect (formation of kidney-shaped cells) was also demonstrated.</p>  a0742-8413