01086nas a2200229   4500000000100000008004100001260000900042653001100051653001200062653002500074653001800099653003900117653001700156100001500173700001500188700001400203245004200217300001000259490000700269520056600276022001400842       1987                            d  c198710aHumans10aleprosy10aMicroscopy, Electron10aMyelin Sheath10aPeripheral Nervous System Diseases10aRadial Nerve1 aJacobs J M1 aShetty V P1 aAntia N H00aMyelin changes in leprous neuropathy.  a75-800 v743 a<p>Myelin changes were observed in fibres of nerves from cases of leprosy. The myelin had a 'loosened' appearance caused by increased and irregular separation of the intraperiod line. 'Loosening' might affect all, or only some, of the lamellae forming a myelin sheath. There was a patchy distribution of fibres with abnormal myelin, and they were seen only in nerves showing other marked pathological changes including the presence of oedema. The appearances are suggestive of intramyelinic oedema which may be related to the presence of endoneurial oedema.</p>  a0001-6322