02543nas a2200277   4500000000100000008004100001260001000042653002100052653001800073653002200091653002600113100001200139700001300151700001400164700001500178700001200193700001400205700001200219700002100231245011600252856005200368300000900420490000700429520181500436022001402251       2025                            d  bLepra10aLazarine leprosy10aUlcer leprosy10aNon-trophic ulcer10anon-neuropathic ulcer1 aBains A1 aBhatia D1 aMandiya S1 aBhardwaj A1 aSingh S1 aBudania A1 aPatra S1 aBandhala Rajan M00aA descriptive study of non-neuropathic ulcers in leprosy: a retrospective study in a tertiary hospital in India  uhttps://leprosyreview.org/article/96/2/20-24111  a1-120 v963 a<p><strong>Background</strong></p>

<p>Cutaneous ulcers sometimes cause diagnostic confusion, whether they are due to disease, reactions or neuropathy. The present study aims to study the non-neuropathic cutaneous ulcers in leprosy.</p>

<p><strong>Methods</strong></p>

<p>Retrospective data from 2015 to 2023 were analyzed. Details were recorded in a pre-designed proforma.</p>

<p><strong>Results</strong></p>

<p>A total of 21 cases with non-neuropathic ulcers were recruited. The mean age was 46 years with a male predominance: 17 (81%). Most of the patients had lepromatous leprosy (LL) 13 (62%). A majority, 18 (86%) suffered from disability. The most common sites of ulceration were the arms and legs: 17 (81%). The most common presentation was crusted nodular-plaque lesions in 12 (56%) patients, followed by erosions over plaques in 4 (19%), ulcers with sloping margins in 2 (10%), punched out ulcers, ulceration in an annular configuration and jagged ulcers in 1 (5%) patient each. ENL was the most common cause of non-neuropathic cutaneous ulceration, clinically suspected in 17 patients (81%) and proven on histopathology in 14 (67%) patients. Chronic and recurrent ENL constituted (8/17 patients, 47%) almost half of the ENL cases. Spontaneous ulceration without any evidence of reaction was noted in 4 patients, BT leprosy in 1 (5%) patient and BL leprosy in 3 (14%) patients.</p>

<p><strong>Conclusion</strong></p>

<p>Most of the patients with non-neuropathic ulcers had LL or BL leprosy, and nearly eighty-five percent suffered from disability. ENL was the most common cause of non-neuropathic cutaneous ulceration, out of which chronic and recurrent ENL constituted half of cases. Spontaneous ulceration without any evidence of reaction was noted in only a few patients.</p>
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