01843nas a2200349   4500000000100000008004100001260001700042653002400059653003100083653002000114653001600134653003000150653002500180653001100205653001200216653002600228653001800254653002500272653002400297653001800321100001400339700001400353700001400367700001400381700001500395700001300410245011400423300001100537490000800548520092300556022001401479       1987                            d  c1987 Sep-Oct10aAntigens, Bacterial10aCell Transformation, Viral10aCells, Cultured10aClone Cells10aCytotoxicity, Immunologic10aHerpesvirus 4, Human10aHumans10aleprosy10aLymphocyte Activation10aMycobacterium10aMycobacterium leprae10aSpecies Specificity10aT-Lymphocytes1 aLaunois P1 aShankar P1 aWallach D1 aFlageul B1 aCottenot F1 aBach M A00aMycobacterium leprae-reactive T-cell clones isolated from polar lepromatous and tuberculoid leprosy patients.  a723-350 v1383 a<p>T-cell clones capable of mounting a proliferative response to Mycobacterium leprae were obtained in three leprosy patients (two polar lepromatous and one polar tuberculoid) either from M. leprae-activated or from protein-purified derivative-activated polyclonal T lymphoblasts. All these clones expressed the CD4 surface marker. Some of them proliferated to the antigen only in the presence of interleukin-2. A majority expressed cross-reactive responses to other mycobacteria. Clones obtained from the lepromatous patients did not differ in any of these features from those obtained from the tuberculoid patient. M. leprae-reactive clones obtained from one lepromatous patient displayed strong antigen-specific cytotoxicity toward autologous antigen-coated target cells. This phenomenon was not observed for any clone of the other lepromatous patient and was seen only for one clone in the tuberculoid patient.</p>  a0769-2625