01237nas a2200265   4500000000100000008004100001260001300042653001000055653001500065653001500080653001100095653001900106653001800125653001200143653000900155653002400164100001200188700001200200700001500212245008200227300001000309490000700319520063100326022001400957       1988                            d  c1988 Feb10aAdult10aCalcitriol10aCyclic AMP10aHumans10aHydroxyproline10aHypercalcemia10aleprosy10aMale10aParathyroid Hormone1 aRyzen E1 aRea T H1 aSinger F R00aHypercalcemia and abnormal 1,25-dihydroxyvitamin D concentrations in leprosy.  a325-90 v843 a<p>Two patients with lepromatous leprosy and hypercalcemia are presented. Serum immunoreactive parathyroid hormone and urinary cyclic adenosine monophosphate concentrations were suppressed. Serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations were elevated in one patient and normal in the other. Urinary hydroxyproline excretion was slightly high in both patients. Hypercalcemia resolved excretion was slightly high in both patients. Hypercalcemia resolved with prednisone therapy. Abnormal 1,25-(OH)2D production and/or metabolism may play a role in the pathogenesis of hypercalcemia in some patients with leprosy.</p>  a0002-9343