01577nas a2200337   4500000000100000008004100001260001300042653001200055653002700067653002200094653001100116653001400127653001600141653002500157653001200182653002500194653002400219653002500243653003900268653001800307100001500325700001300340700001500353700001300368700001300381245008300394300001100477490000700488520073000495022001401225       1988                            d  c1988 Jun10aAnimals10aDisease Models, Animal10aElectrophysiology10aFemale10aGranuloma10aGuinea Pigs10aImmunohistochemistry10aleprosy10aMicroscopy, Electron10aMycobacterium bovis10aMycobacterium leprae10aPeripheral Nervous System Diseases10aSciatic Nerve1 aCowley S A1 aButter C1 aVerghese S1 aCurtis J1 aTurk J L00aNerve damage induced by mycobacterial granulomas in guinea pig sciatic nerves.  a283-900 v563 a<p>A possible model for nerve damage in leprosy has been developed in the sciatic nerve of the guinea pig. Intraneural injection of 10(7) BCG organisms into an unsensitized animal induces an epithelioid cell granuloma in 2 weeks similar to that found in tuberculoid leprosy patients. In contrast, intraneural injection of 10(9) cobalt-irradiated Mycobacterium leprae organisms induces a macrophage granuloma in 5 weeks, similar to that found in lepromatous leprosy patients. Histological, immunohistochemical, electron microscopical and electrophysiological studies have demonstrated that the lesions induced in the experimental animals show many of the features documented in studies of nerve damage in leprosy patients.</p>  a0148-916X