01852nas a2200373   4500000000100000008004100001260001300042653001200055653001100067653001400078653001800092653001300110653001800123653001600141653000900157653002400166653002500190653003200215100001500247700001600262700001400278700001300292700001100305700001600316700001400332700001400346700001000360700001600370245014600386300001100532490000700543520091400550022001401464       1989                            d  c1989 Jun10aAnimals10aFemale10aGranuloma10aInterleukin-110aKinetics10aLung Diseases10aMacrophages10aMice10aMice, Inbred BALB C10aRecombinant Proteins10aTumor Necrosis Factor-alpha1 aKasahara K1 aKobayashi K1 aShikama Y1 aYoneya I1 aKaga S1 aHashimoto M1 aOdagiri T1 aSoejima K1 aIde H1 aTAKAHASHI T00aThe role of monokines in granuloma formation in mice: the ability of interleukin 1 and tumor necrosis factor-alpha to induce lung granulomas.  a419-250 v513 a<p>Granulomatous inflammation is associated with many significant human diseases, including tuberculosis, leprosy, sarcoidosis, parasite infection, and berylliosis. Very little is known about the basic mechanism of this type of inflammation. In the present study, we showed that pulmonary granulomas were induced in mice by the intratracheal injection of agarose beads coupled to recombinant interleukin 1 (IL-1) or tumor necrosis factor-alpha (TNF-alpha). Histologically, the bulk of granulomas was composed of macrophages and their derivatives. In contrast, the inflammatory reactions induced by beads coupled to either recombinant IL-2 or murine interferon-gamma were considerably smaller than those induced by beads coupled to monokines. These results suggest that macrophages and monokines such as IL-1 and TNF-alpha, but not T cell-derived lymphokines, play an essential role in granuloma formation.</p>  a0090-1229