02189nas a2200409   4500000000100000008004100001260001300042653002200055653001000077653003000087653002100117653001100138653001400149653001100163653001600174653002100190653002500211653000900236653002900245100001300274700001500287700001300302700001300315700001300328700001300341700001100354700001700365700001100382700001300393245013300406856009000539300001000629490000700639050001500646520110400661022001401765       1989                            d  c1989 Jun10aAcetylglucosamine10aAdult10aCarbohydrate Conformation10aErythema Nodosum10aFemale10aGalactose10aHumans10aImmunoassay10aImmunoglobulin G10aLeprosy, lepromatous10aMale10aReceptors, Interleukin-21 aFilley E1 aAndreoli A1 aSteele J1 aWaters M1 aWagner D1 aNelson D1 aTung K1 aRademacher T1 aDwek R1 aRook G A00aA transient rise in agalactosyl IgG correlating with free interleukin 2 receptors, during episodes of erythema nodosum leprosum.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541882/pdf/clinexpimmunol00087-0029.pdf  a343-70 v76  aFILLEY19893 a<p>The proportion of oligosaccharide chains on the Fc fragment of IgG which terminate with N-acetylglucosamine and not galactose (%GO) has previously been shown to be raised in rheumatoid arthritis (RA), Crohn's disease (CD) and tuberculosis (Tb), but to be normal in sarcoidosis (SA), and in both lepromatous and tuberculoid leprosy. However we have now studied %GO in sequential serum samples collected from lepromatous leprosy patients undergoing episodes of erythema nodosum leprosum (ENL). During ENL %GO is transiently raised, and this rise parallels an increase in circulating interleukin 2 receptors (IL-2R). These findings confirm that changes in T cell function occur during ENL. Moreover it appears that %GO rises when there is, simultaneously, T-cell-mediated tissue damage and an acute phase response (RA, CD, Tb, ENL), but not when there is an acute phase response without major T cell involvement, or chronic T cell activity alone (SA, and tuberculoid leprosy). We suggest therefore that %GO is an indicator of a type of T cell activity with broad immunopathological implications.</p>  a0009-9104