01436nas a2200253   4500000000100000008004100001260000900042653003000051653001100081653001400092653002300106653001200129653001800141653002100159653001700180100001600197700001600213700001500229245021600244300001000460490000700470520069100477022001401168       1989                            d  c198910aDrug Therapy, Combination10aHumans10aIsoniazid10aIsonicotinic Acids10aleprosy10aProthionamide10aSulfamethoxazole10aTrimethoprim1 aFreerksen E1 aRosenfeld M1 aSpannuth G00aNew forms of multidrug therapy for the treatment of leprosy. First report for the practice on rifampicin + sulfamethoxazole-trimethoprim + protionamide and rifampicin + sulfamethoxazole-trimethoprim + isoniazid.  a133-90 v353 a<p>Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide + DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years. The present paper describes the attempts made to find solutions to these problems. With two new combinations, alternatives have become available, and the average treatment time is shortened to 6 months. Both combinations are also effective in tuberculosis.</p>  a0009-3157