01088nas a2200217   4500000000100000008004100001260001200042653001700054653001200071653002600083100001100109700001000120700001100130700001000141700001000151700001000161700001200171245005600183520061700239022001400856       2024                            d  c10/202410aNerve injury10aLeprosy10aMycobacterium leprae 1 aGeng H1 aBao F1 aWang C1 aSun L1 aXue X1 aLiu H1 aZhang F00aIL-22 in Mycobacterium leprae-induced Nerve injury.3 a<p>The neurotropism of M. leprae is a unique characteristic that distinguishes it from other mycobacteria and is also the main cause of deformity in patients. However, the mechanism of peripheral nerve injury is still unclear. In the present study, immunohistochemistry and qPCR showed that the skin lesions of leprosy patients were significantly higher than those of other mycobacterium infected skin lesions, and IL-22 was concentrated around the cutaneous nerves. Further study found that IL-22 is involved in disease by regulating neuroinflammation and promoting apoptosis through the JAK-STAT pathway.</p>
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