02381nas a2200253   4500000000100000008004100001260002000042653003000062653002200092653001500114653002300129100001700152700001600169700001700185700002000202700001900222700001800241245008800259856007300347300001400420490000600434520166200440022002502102       2024                            d  bGreen Publisher10aanemia on chronic disease10aerythrocyte index10aleprosy   10aMulti-drug therapy1 aSetyawati NK1 aRusyati LMM1 aIndira IGAAE1 aPraharsini IGAA1 aDarmaputra IGN1 aKarmila IGAAD00aAnemia on Chronic Disease in Leprosy Before and After Completing Multi Drug Therapy  uhttps://eduvest.greenvest.co.id/index.php/edv/article/view/1500/2776  a8409-84170 v43 a<jats:p>Leprosy infection can cause anemia due to chronic disease (ACD). Multidrug therapy (MDT) for leprosy patients can overcome the infection. This study aims to determine the comparison in the incidence of ACD before and three months after MDT to leprosy patients at Prof. Dr. I G.N.G. Ngoerah Central General Hospital. A cross-sectional analytical observational study was conducted using secondary data from medical records of leprosy patients. A total of 142 samples were taken through total sampling. Data taken included gender, domicile, type of leprosy suffered, incidence of ACD, hemoglobin levels, and erythrocyte index before and three months after completing MDT leprosy therapy. Data analysis was carried out with SPSS version 21 using chi-square and paired t tests (dependent t-test), p value &lt;0.05 means significant. The incidence of ACD was significantly higher before leprosy MDT therapy compared to 3 months after completing leprosy MDT therapy (49.3% vs. 16.2%; p value &lt;0.001) with a prevalence ratio of 3.043 (2.021-4.584) CI95%. The mean hemoglobin levels, MCV, MCH, and MCHC levels 3 months after MDT leprosy therapy were significantly higher than before receiving MDT therapy (13.73 ± 1.47 vs. 12.40 ± 2.06 g/dL; p value &lt;0.001), (88.18±7.22 vs. 84.07±9.55 fl; p value&lt;0.001), (28.32±2.76 vs. 26.72±3.17 pg/cell; p value &lt;0.001), (32.03±1.30 vs. 31.69±1.47%; p value&lt;0.001). The incidence of ACD was significantly higher before MDT compared to 3 months after MDT. Mean hemoglobin, MCV, MCH, and MCHC levels were found to be significantly higher 3 months after MDT compared to before receiving MDT.</jats:p>  a2775-3727, 2775-3735