01791nas a2200301   4500000000100000008004100001260001700042653000900059653002200068653002100090653001100111653002300122653002800145653001200173653002500185653002500210653000900235653001600244100001300260700001400273700001200287700001400299245005600313300001000369490000700379520108900386022001401475       1989                            d  c1989 Apr-Jun10aAged10aAged, 80 and over10aErythema Nodosum10aHumans10aImmunity, Cellular10aImmunoenzyme Techniques10aleprosy10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMiddle Aged1 aFujita M1 aMiyachi Y1 aIzumi S1 aImamura S00a[Cell mediated immune response in leprosy lesions].  a85-910 v583 a<p>Five biopsies from 2 leprosy patients, tuberculoid (TT), and polar lepromatous (LLp), were studies using immunoperoxidase procedures with monoclonal antibodies. Immunohistochemical patterns of them were remarkably different. In a TT patient, epithelioid cells and helper/inducer T (Leu 3a+) cells made the central core of a granuloma surrounded by suppressor/cytotoxic T (T8+) cells and B cells, indicating a possible immune-mediated cell response. The distribution of B cells suggests that not only T but also B cells may take part in the formation of the granuloma. In contrast, helper/inducer cells, suppressor/cytotoxic cells, and macrophages of a LLp patient were admixed uniformly at the site of the lesion, indicating a poor immune response. Although the ENL skin lesion of this LLp patient did not eliminate the bacilli, HLA-DR expression by keratinocytes and increased numbers of helper/inducer cells found in an ENL lesion, comparable to the findings of TT leprosy, suggests that a cell mediated immune response may play some role in the pathogenesis of ENL reaction.</p>  a0386-3980