01422nas a2200289 4500000000100000008004100001260001300042653001600055653001200071653002000083653003100103653003000134653002000164653001100184653001200195653001300207100002200220700001400242700001400256700001400270245007800284300001200362490000700374050002200381520071500403022001401118 1989 d c1989 Apr10aClofazimine10aDapsone10aDrug Evaluation10aDrug Resistance, Microbial10aDrug Therapy, Combination10aHospitalization10aHumans10aleprosy10aRifampin1 aChattopadhyay S P1 aGupta C M1 aBhate R D1 aBhate R P00aEvaluation of two multidrug regimen in hospitalised multibacillary cases. a196-2050 v61 achattopadhyay19893 a
Fifty three multibacillary leprosy cases were treated with two regimens of MDT L1 consisting of Rifampicin, Dapsone and Ethionamide and L2 consisting of Rifampicin, Dapsone and clofazimine. The results were compared at regular intervals and at the end of the study (24 months). Clinical inactivity, bacteriological negativity, ENL reactions, upgrading reactions were seen in L1 group in 65%, 4.54%, 50% and 41% of cases respectively while 65%, 25.8%, 30% and 45% respectively in L2 regimen group. Zero percent morphological Index was achieved in all cases in L1 regimen 90% in L2 regimen cases. No viability was found on mouse foot pad inoculation after 6 months in L1 while after 18 months in L2 cases.
a0254-9395