01231nas a2200205   4500000000100000008004100001260001600042653002000058653003200078653002100110653003300131653001200164100001800176700000900194700001100203245018900214490000700403520060100410022001401011       2024                            d  bElsevier BV10aNuclear Factor 10aKappa Beta (NF-κB) Pathway10aCytokine Cascade10aPotential Therapeutic Target10aLeprosy1 aChakraborty D1 aDe A1 aHena A00a54750 A Cross-Sectional Study to Evaluate the Role of the Nuclear Factor Kappa Beta (NF-κB) Pathway in Regulating the Cytokine Cascade and as a Potential Therapeutic Target in Leprosy0 v913 a<p>Pattern recognition receptors (PRR), such as Toll-like receptors (TLRs) and NOD-like receptors (NLRs) found in microorganisms but not hosts, allow Leprae bacilli to be recognized as foreign. Sen and Baltimore discovered the transcription factor nuclear factor kappa-B (NF-B), employed by eukaryotic cells to regulate immunity, cell differentiation, and proliferation. This study aimed to evaluate the role of the nuclear factor kappa B (NF-B) pathway in controlling the cytokine cascade in leprosy due to a lack of understanding of the link between cytokines and the severity of leprosy.</p>
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