01682nas a2200301   4500000000100000008004100001260001300042653001500055653001200070653001100082653001100093653001200104653000900116653002300125653002200148653002400170100001600194700001200210700001100222700001100233700001300244245011700257300001000374490000700384050003200391520094300423022001401366       1989                            d  c1989 Jul10aCreatinine10aDapsone10aFemale10aHumans10aleprosy10aMale10aPatient Compliance10aRandom Allocation10aSelf Administration1 aBhatnagar P1 aKumar B1 aKaur S1 aKaur I1 aSeghal S00aDapsone drug compliance study among leprosy patients: a comparison between qualitative and quantitative methods.  a373-80 v61  aInfolep Library - available3 a<p>The methods currently employed to monitor self-administration of dapsone have been evaluated by comparing the results of the qualitative spot test and quantitative DDS/creatinine ratio test. Random urine samples of 242 leprosy patients, periodically attending the Leprosy Clinic were tested. Although a good correlation between the results of the two tests was evident, the DDS/creatinine ratio technique appeared to be more sensitive than the spot test. The concentration of DDS and its metabolites in urine specimens found to be negative by the spot test, ranged from 3.32-12.37 micrograms of DDS/mg creatinine. The spot test was found to be more specific and stays to be the method of choice, when rapidity and reproducibility are the prime objectives, and sensitivity can be marginally compromised. Acidification of urine prior to the spot test was found to be desirable to rule out false negative and false positive reactions.</p>  a0254-9395