01404nas a2200241   4500000000100000008004100001260001300042653002500055653001200080653003300092653003000125653001100155653001200166653002500178653001300203100001200216700001300228245005800241300000900299490000700308520083300315022001401148       1989                            d  c1989 Feb10aAdministration, Oral10aDapsone10aDrug Administration Schedule10aDrug Therapy, Combination10aHumans10aleprosy10aMycobacterium leprae10aRifampin1 aKar P K1 aSohi A S00aStudy of multidrug therapy in paucibacillary leprosy.  a34-60 v873 a<p>A study was undertaken to evaluate the efficacy of multidrug therapy (MDT) in paucibacillary leprosy. Out of 155 fresh cases studied 48 had indeterminate, 38 tuberculoid and 69 had borderline tuberculoid leprosy. Out of 155 cases, 64 patients in the first group were treated with dapsone 100 mg daily for 12 months. In the second group, 91 patients were given MDT, consisting of rifampicin 600 mg once a month and dapsone 100 mg daily for consecutive 12 months. The cases receiving dapsone and the cases having MDT remained clinically active at the end of 6 months in 56.1% and 37.2% respectively; 13.1% of cases having single lesion and 66.3% of patients with multiple lesions were found to be active after 6 months of MDT. At the end of one year 79.6% cases receiving dapsone and 91.2% cases having MDT became inactive.</p>  a0019-5847