02184nas a2200349   4500000000100000008004100001260001300042653002400055653002300079653001600102653001000118653002100128653001100149653001200160653002500172653001500197653001600212653002600228100001700254700001700271700001800288700001400306700001400320700001500334700001500349700001300364245007500377300001000452490000700462520135100469022001401820       1989                            d  c1989 Mar10aAntigens, Bacterial10aBacterial Vaccines10aBCG Vaccine10aChild10aChild, Preschool10aHumans10aleprosy10aMycobacterium leprae10aSkin Tests10aVaccination10aVaccines, Inactivated1 aStanford J L1 aStanford C A1 aGhazi Saidi K1 aDowlati Y1 aWeiss S F1 aFarshchi Y1 aMadlener F1 aRees R J00aVaccination and skin test studies on the children of leprosy patients.  a38-440 v573 a<p>In an attempt to achieve maximal skin-test positivity to leprosin A in children of leprosy patients living in Baba Baghi Leprosy Sanatorium in Iranian Azerbaijan, two new vaccines have been employed. Children without scars of previous BCG and without response to leprosin A were given a vaccine containing 10(8) viable units of BCG Glaxo plus 10(7) killed Mycobacterium vaccae per dose (vaccine B). Children with BCG Pasteur (Teheran) scars but without response to leprosin A were given a vaccine containing 10(8) killed M. vaccae alone (vaccine D). Eight years later skin testing was repeated, and both new vaccines were found to have significantly increased the numbers of children responding to leprosin A above the level that would have been expected had they received BCG Pasteur alone. This increase was due in large part to increases in the proportions of individuals responding to group i (common mycobacterial) antigens, and known as category 1 responders. The use of suspensions of killed M. vaccae in conjunction with BCG may represent a considerable advance in inducing protection from multibacillary leprosy in close contacts of leprosy patients if leprosin A positivity is truly a correlate of protective immunity. A comparison, using the same criteria, with the other proposed vaccines for leprosy would be very interesting.</p>  a0148-916X