@article{9965, keywords = {Adolescent, Child, Child, Preschool, Fluorescent Antibody Technique, Follow-Up Studies, Humans, Infant, Lepromin, leprosy}, author = {Bharadwaj V P and Katoch K}, title = {Detection of subclinical infection in leprosy: an 8 years follow-up study.}, abstract = {

A follow-up study has been carried out using Fluorescent Leprosy Antibody Absorption (FLA-ABS) test in 1069 healthy contacts of multi and pauci-bacillary leprosy patients. Simultaneously lepromin testing with Dharmendra antigen has also been done to determine their delayed type hypersensitivity. In nearly 8 years of follow-up, 46 contacts have developed disease and of these 41 contacts were FLA-ABS positive and lepromin negative. It is inferred that test (along with lepromin) can be used to identify the contacts who are at higher risk of developing the disease. FLA-ABS test has also been found to be highly sensitive for detection of subclinical infection specially in younger age groups. This test could therefore serve as a very sensitive epidemiological tool for assessing the extent of disease in the community and for monitoring the transmission of disease especially after MDT and other intervention measures.

}, year = {1989}, journal = {Indian journal of leprosy}, volume = {61}, pages = {495-502}, month = {1989 Oct}, issn = {0254-9395}, language = {eng}, }