@article{9891, keywords = {Animals, Armadillos, Chromatography, Thin Layer, Glycolipids, leprosy, Lipids, Liver, Magnetic Resonance Spectroscopy, Molecular Structure, Mycobacterium leprae, Phenols, Spleen}, author = {Daffé M and Lanéelle M A}, title = {Diglycosyl phenol phthiocerol diester of Mycobacterium leprae.}, abstract = {

A diglycosyl phenol phthiocerol diester that had not been previously detected was isolated from M. leprae-infected armadillo tissues. Spectroscopy methods allowed the elucidation of its structure. The diglycoside was a 2,3-di-O-methylrhamnopyranosyl (alpha 1----2)3-O-methylrhamnopyranosyl (alpha 1-linked to the phenolic hydroxyl of phthiocerol dimycocerosates). It differs from the major phenolic glycolipid (PGL I) only by the absence of the terminal 3,6-di-O-methylglucopyranosyl unit. The diglycoside could be an intermediate in the synthesis of the latter antigen or a degradative product in the host detoxification process.

}, year = {1989}, journal = {Biochimica et biophysica acta}, volume = {1002}, pages = {333-7}, month = {1989 Apr 26}, issn = {0006-3002}, doi = {10.1016/0005-2760(89)90347-0}, language = {eng}, }