@article{9874,
  keywords = {Animals, Antibody Formation, Enzyme-Linked Immunosorbent Assay, leprosy, Macaca mulatta, Mycobacterium leprae, Retroviridae Infections, Simian immunodeficiency virus},
  author = {Gormus B J and Murphey-Corb M and Martin L N and Zhang J Y and Baskin G B and Trygg C B and Walsh G P and Meyers W M},
  title = {Interactions between simian immunodeficiency virus and Mycobacterium leprae in experimentally inoculated rhesus monkeys.},
  abstract = {<p>Thirty-four rhesus monkeys were inoculated with Mycobacterium leprae inoculum isolated from sooty mangabey monkeys with leprosy. Later it was learned that one of the M. leprae-donor mangabeys was asymptomatically infected with simian immunodeficiency virus (SIV). Thus, five of the rhesus monkey were coinoculated with M. leprae and SIV. Three of the five became SIV-positive and developed signs of leprosy and an AIDS-like illness. Two animals remained healthy. The coinoculated leprosy-positive rhesus monkeys developed leprosy despite serologic response patterns to M. leprae antigens that usually indicate leprosy resistance. Three (60%) of the five SIV-positive rhesus monkeys developed leprosy compared with 21% of the animals who received SIV-free M. leprae inocula. Diminished lepromin skin test responses and decreasing T-helper cell percentages were observed in SIV-coinoculated rhesus monkeys with leprosy. These observations suggest that SIV increases the susceptibility of rhesus monkeys to leprosy, possibly related to loss of T-helper cell function.</p>},
  year = {1989},
  journal = {The Journal of infectious diseases},
  volume = {160},
  pages = {405-13},
  month = {1989 Sep},
  issn = {0022-1899},
  doi = {10.1093/infdis/160.3.405},
  language = {eng},
}