@article{9808,
  keywords = {Antigens, Bacterial, Genes, MHC Class II, HLA Antigens, Humans, leprosy, Mycobacterium, Mycobacterium leprae, Mycobacterium tuberculosis, T-Lymphocytes, Tuberculosis},
  author = {Vries R R},
  title = {Regulation of T cell responsiveness against mycobacterial antigens by HLA class 2 immune response genes.},
  abstract = {<p>Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.</p>},
  year = {1989},
  journal = {Reviews of infectious diseases},
  volume = {11 Suppl 2},
  pages = {S400-3},
  month = {1989 Mar-Apr},
  issn = {0162-0886},
  doi = {10.1093/clinids/11.supplement_2.s400},
  language = {eng},
}