@article{9779,
  keywords = {Cell Migration Inhibition, Cross Reactions, Epitopes, Female, Humans, In Vitro Techniques, leprosy, Lymphocyte Activation, Male, Mycobacterium leprae, Mycobacterium tuberculosis, T-Lymphocytes, Vaccination},
  author = {Rawlinson W D and Basten A},
  title = {Cross-reactivity of Mycobacterium leprae and M. tuberculosis and the implications for assessment of in vitro T cell function in leprosy patients.},
  abstract = {<p>The cross-reactivity in vitro between Mycobacterium leprae and M. tuberculosis was studied in 41 Aboriginal Australians with leprosy, 78 uninfected contacts of leprosy patients and 38 control individuals. A vigorous T cell response to epitopes cross-reactive between these two mycobacteria was found for healthy uninfected contacts or non-contacts (controls) of leprosy patients, but not for the patients themselves. The data suggest that a vaccine based on antigen shared between M. leprae and other mycobacteria is unlikely to be useful in preventing leprosy. Further studies of responses in vitro to purified T cell-reactive antigens would be useful in designing newer vaccines for more widespread field studies of leprosy prevention.</p>},
  year = {1989},
  journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
  volume = {83},
  pages = {557-9},
  month = {1989 Jul-Aug},
  issn = {0035-9203},
  doi = {10.1016/0035-9203(89)90294-0},
  language = {eng},
}