@article{9764,
  keywords = {Adjuvants, Immunologic, Animals, Dapsone, Depression, Chemical, Disease Models, Animal, Drug Therapy, Combination, Foot, leprosy, Mice, Mice, Nude, Mycobacterium leprae},
  author = {Gidoh M and Tsutsumi S},
  title = {The inhibitory effects by combined doses of DDS and several immunostimulants on the growth of leprosy bacilli inoculated into footpads of hybrid nude mice, Jcl:AF-nu.},
  abstract = {<p>The inhibitory effects by the combined doses of bacteriostatic DDS and several immunostimulants on the growth of leprosy bacilli (LB) inoculated into the footpads of nude mice were examined, using a strain of hybrid nude mice named Jcl:AF-nu, which is resistible to infections more than strain BALB/c-nu. The results found were: 1. LB could proliferate up to 10(9) level in the footpads of this strain of hybrid nude mice. 2. The combined dose of muramyl dipeptide (MDP) or a water-soluble lipoidal amine, CP-46665 and DDS mixed with chow in the content ratio of 0.005% completely inhibited the growth of LB. Whereas, the growth inhibition by DDS alone was only partial. 3. A derivative of MDP, muroctasin could partially inhibit the growth of LB without combined dose of DDS. 4. The combined dose of an antitumor beta-1, 3-glucan named ATSO could not enhance the partial growth inhibition due to the dose of DDS through 0.005%-DDS chow. Based on these results, the possibility of Jcl:AF-nu mice as a favorable animal model for examining the synergic inhibitory effect on the growth of LB due to the combined dose of an antileprous chemotherapeutic and an immunostimulant was discussed.</p>},
  year = {1989},
  journal = {Nihon Rai Gakkai zasshi},
  volume = {58},
  pages = {241-9},
  month = {1989 Oct-Dec},
  issn = {0386-3980},
  doi = {10.5025/hansen1977.58.241},
  language = {eng},
}