@article{9763,
  keywords = {4-Quinolones, Animals, Anti-Infective Agents, Female, Fluoroquinolones, Foot, leprosy, Mice, Mice, Nude, Mycobacterium leprae},
  author = {Tsutsumi S and Gidoh M},
  title = {Studies on the development of novel anti-leprous chemotherapeutics using nude mice with special reference to a new quinolone carboxylic acid, AT-4140.},
  abstract = {<p>In order to develop a novel drug for antileprosy chemotherapy, the inhibitory effects of three synthesized compounds, a supplied antituberculous one and three quinolone carboxylic acids were examined on the growth of leprosy bacilli inoculated into the footpads of nude mice. Amongst them, a new quinolone carboxylic acid, AT-4140 whose chemical structure was 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(cis-3, 5-dimethyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid strongly inhibited the growth of leprosy bacilli at doses of 15 and 30 mg/kg. Whereas, the effect of Ofloxacin used as a positive control was limited at the same doses.</p>},
  year = {1989},
  journal = {Nihon Rai Gakkai zasshi},
  volume = {58},
  pages = {250-8},
  month = {1989 Oct-Dec},
  issn = {0386-3980},
  doi = {10.5025/hansen1977.58.250},
  language = {eng},
}