@article{9715,
  keywords = {Arthritis, Rheumatoid, Epitopes, Genes, MHC Class II, HLA-DR4 Antigen, Histocompatibility Antigens Class II, Histocompatibility Testing, Humans, leprosy, Mycobacterium, Mycobacterium tuberculosis, Skin Tests},
  author = {Ottenhoff T H and Torres P and De Las Aguas J T and Fernandez R and Eden W and Vries R R and Stanford J L},
  title = {Evidence for an HLA-DR4-associated immune-response gene for Mycobacterium tuberculosis. A clue to the pathogenesis of rheumatoid arthritis?},
  abstract = {<p>Antigens of Mycobacterium tuberculosis, M leprae, M scrofulaceum, and M vaccae were injected intradermally in 86 caucasoid leprosy patients, and skin responses (measured in mm of induration at 72 h) were analysed in relation to HLA class II phenotypes. HLA-DR4 was associated with high responsiveness to antigens specific to M tuberculosis but not to antigens shared with other mycobacteria (p = 0.0005). Because DR4 is associated with rheumatoid arthritis (RA) and because a role for M tuberculosis antigens has been suggested both in experimentally induced autoimmune arthritis in rats and in RA, the DR4 associated regulation of the immune response to M tuberculosis may be relevant to the pathogenesis of RA.</p>},
  year = {1986},
  journal = {Lancet (London, England)},
  volume = {2},
  pages = {310-3},
  month = {1986 Aug 09},
  issn = {0140-6736},
  doi = {10.1016/s0140-6736(86)90004-8},
  language = {eng},
}