@article{97086,
  keywords = {General Medicine},
  author = {Yuniati R and Riawan W and Widayati A and Khrisna MB and Kristina TN},
  title = {Histopathology of SUMO in TGF-β1 signaling in neural lesions of leprosy reversal reactions},
  abstract = {<p>Background Neural lesions are one of the main pathologies occurring in leprosy, which can result in devastating consequences due to disability and deformity. Transforming Growth Factor β (TGF-β) is important in the development of tissue fibrosis. The signaling process for TGF-β starts when it binds to TβRI and TβRII, activating and inducing the phosphorylation of Smad2 and Smad3. SUMOylation is a posttranslational modification, mediating the phosphorylation of Smad3 and regulating the TGF-β response. S100b is a marker of nerve damage. Objectives This study evaluates the in-vivo expression levels of SUMO-1 and SUMO2/3/4, the distribution of Schwann cells and mononuclear cells, and the distribution of S100b and collagen-1 in nerve biopsies of patients with leprosy reversal reactions. Methods Biopsies from twenty-six leprosy patients with reversal reactions (RR) and twenty-four leprosy patients without reversal reactions were stained for SUMO-1, SUMO-2/3/4, S100b, and collagen. We analyzed the cells using a Nikon microscope under 400× magnification. Results We found an increased distribution of SUMO-1, SUMO-2/3/4, macrophages, S100b, and collagen staining in neural lesions of reversal reaction patients, compared to leprosy patients without reversal reactions. Conclusion TGF-β plays an important role in the development of fibrosis in the neural lesions of patients with leprosy. Regulation of the transcription process is mediated by TGF-β1 signaling by SUMO-1 and/or SUMO-2/3/4. The increase in macrophages and collagen, with the decrease in S100b, in patients with neural lesions reflects the&nbsp; damage to nerves in leprosy reversal reactions.</p>
},
  year = {2022},
  journal = {Leprosy Review},
  volume = {93},
  pages = {138-148},
  publisher = {Lepra},
  issn = {2162-8807},
  url = {https://leprosyreview.org/admin/public/api/lepra/website/getDownload/6298a32fafaac119da731702},
  doi = {10.47276/lr.93.2.138},
  language = {eng},
}