@article{945,
  keywords = {Animals, Dapsone, Drug Resistance, Microbial, Humans, Leprostatic Agents, leprosy, Mice, Mice, Inbred CBA, Mycobacterium leprae, Philippines, Prevalence},
  author = {Cruz E and Cellona R V and Balagon M V and Villahermosa L G and Fajardo T T and Abalos R M and Tan E V and Walsh G P},
  title = {Primary dapsone resistance in Cebu, The Philippines; cause for concern.},
  abstract = {<p>At a time when primary dapsone resistance was prevalent in many leprosy endemic areas, Cebu in The Philippines reported only 3.6% in the period 1975-1978 and later 8.1% in the period 1979-1982. In our current study of patients in the period 1988-1992, the number increased dramatically to 52.7%. In addition, 7.9% of the isolates are highly resistant to dapsone, a level of resistance not seen in earlier studies. This finding could have severe ramifications to the World Health Organization's multidrug therapy (WHO-MDT) mode of treatment, where dapsone is one of the principal drugs. Moreover, the increase in primary dapsone resistance may be a contributing factor in the recent finding that there has been no decline in the number of new cases found in Cebu, even after the implementation of WHO-MDT in 1985. There is a need for new drugs that could be included in the multidrug treatment for multibacillary and paucibacillary leprosy.</p>},
  year = {1996},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {64},
  pages = {253-6},
  month = {1996 Sep},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v64n3a01.pdf},
  language = {eng},
}