@article{9442,
  keywords = {Adenosine Triphosphate, Animals, Chromatography, High Pressure Liquid, Dapsone, Drug Interactions, Leprostatic Agents, leprosy, Mice, Mice, Inbred BALB C, Microbial Sensitivity Tests, Mycobacterium leprae, Receptors, Fc, Thymidine, Trimethoprim},
  author = {Seydel J K and Wempe E G and Rosenfeld M and Jagannathan R and Mahadevan P R and Dhople A M},
  title = {In vitro and in vivo experiments with the new inhibitor of mycobacterium leprae brodimoprim alone and in combination with dapsone.},
  abstract = {<p>The antibacterial effect of brodimoprim alone and in combination with dapsone has been studied in vitro in cell-free systems and in whole mycobacterial cells as well as in vivo in mice and humans. The obtained inhibitory effects in vitro and in vivo against model mycobacterial strains and M. leprae, the pharmacokinetic properties in human and its synergistic effect with the most used drug in the chemotherapy of leprosy, dapsone, make brodimoprim a promising candidate in the therapy of leprosy.</p>},
  year = {1990},
  journal = {Arzneimittel-Forschung},
  volume = {40},
  pages = {69-75},
  month = {1990 Jan},
  issn = {0004-4172},
  language = {eng},
}