@article{94332,
  author = {Belopasov V V},
  title = {Typology and pathogenesis of neuropathic pain with leprosy},
  abstract = {Leprosy is an infectious disease with predominant damage to the skin and peripheral nerves. In the Russian Federation, cases of the disease are rare and of a sustained sporadic nature. One of the active centers on its territory is Astrakhan region. An organism vulnerability to infection is determined by the genetically determined predisposition to the penetration of a pathogen into the tissues of the human body, congenital malformations of the macrophage link and T-lymphocytes functioning of the host organism. Mycobacterium leprae, bypassing the tissue histo-hematic barriers, are introduced into the endothelium of capillaries, where they undergo their development cycle. Having passed it, the bacteria with the blood flow rush to the target organs, primarily to the skin and peripheral nerves. Diagnosis verification is based on the results of histological evaluation of skin biopsy specimens, lepromin skin test, polymerase chain reaction (PCR), determination of the antibody production intensity, antigens by enzyme immunoassay (ELISA), bacterioscopy of nasal mucosa scrapes, and skin scarification. Leprosy is a treatable form of pathology. For etiotropic combination therapy, antileprosy drugs are used (rifampicin, dapson and others), antibiotics (minocyclin, clarithromycin) according to the regimens proposed by the WHO, with a prescription of 2 drugs and immunomodulating agents. Treatment is carried out before the disappearance of the pathogen in skin biopsy specimens.},
  year = {2018},
  journal = {Russian Medical Review},
  volume = {9},
  pages = {41–45},
  url = {https://www.rusmedreview.com/upload/iblock/048/41-45.pdf},
  language = {rus},
}