@article{9423,
  keywords = {Adolescent, Adult, Antibodies, Bacterial, Antigens, Bacterial, Child, Female, Glycolipids, Humans, Immunoglobulin M, leprosy, Longitudinal studies, Male, Mycobacterium leprae, Papua New Guinea},
  author = {Bagshawe A F and Garsia R J and Baumgart K and Astbury L},
  title = {IgM serum antibodies to phenolic glycolipid-I and clinical leprosy: two years' observation in a community with hyperendemic leprosy.},
  abstract = {<p>A village population with hyperendemic leprosy in Papua New Guinea was repeatedly examined for clinical leprosy and for serum IgM antibodies to phenolic glycolipid-I (APGL-I) over 2 years between 1984 and 1986. In 1984, serum APGL-I was elevated in 15% of the subjects without clinical leprosy, and the prevalence of seropositivity was not significantly different in subjects from households with or without leprosy. In 1986, the prevalence of elevated serum APGL-I in leprosy-free subjects had risen to 23%. The incidence of seroconversion from APGL-I negative to APGL-I positive was 9.5% per year (95/1000 person years) in 253 subjects tested in 1984 and 1986. During the same period, 27 of 40 (67%) leprosy-free subjects reverted from positive to negative. The positive seroconversion rate in the community was higher than the incidence of clinical leprosy (11.2/1000 person years) over the same period. However, elevated serum APGL-I was not associated with clinical disease and failed to predict the development of disease over 2 years. The significance of persistent seropositivity found in 14 (5%) leprosy-free subjects is uncertain.</p>
},
  year = {1990},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {58},
  pages = {25-30},
  month = {1990 Mar},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v58n1a04.pdf},
  language = {eng},
}