@article{93768,
  author = {Choi H and Cho S and Ha Y and Ocampo B and Park S and Chen S and Bennett C and Han J and Rossner R and Kang J and Lee Y and Park S and Kaeberlein M},
  title = {DDS promotes longevity through a microbiome-mediated starvation signal.},
  abstract = {<p>The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in  through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in  by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.</p>},
  year = {2019},
  journal = {Translational medicine of aging},
  volume = {3},
  pages = {64-69},
  month = {01/2019},
  issn = {2468-5011},
  url = {https://www.sciencedirect.com/science/article/pii/S2468501119300045?via%3Dihub},
  doi = {10.1016/j.tma.2019.07.001},
  language = {eng},
}