@article{9373,
  keywords = {Adult, Antigens, Bacterial, Cells, Cultured, Female, Glycolipids, Humans, leprosy, Lipids, Male, Middle Aged, Monocytes, Mycobacterium leprae, Oxidation-Reduction, Superoxides},
  author = {Vachula M and Worobec S and Andersen B R},
  title = {A comparison of monocyte oxidative responses in leprosy patients and healthy subjects as influenced by mycobacterial lipid pretreatment.},
  abstract = {<p>Superoxide anion (O2-) release by monocytes from leprosy patients in a paired study was lower than that released by monocytes from healthy controls. Pretreatment of healthy control monocytes with phenolic glycolipid-I (PGL-I) of Mycobacterium leprae resulted in the release of less O2- than released by buffer-treated cells or cells pretreated with structurally similar lipids. However, pretreatment of patient monocytes with PGL-I did not affect the O2- generation, perhaps because the cells already had a lower capacity to produce O2-. Upon further examination of the data from the patient population, monocytes from lepromatous patients released significantly less O2- than cells from normal controls, while tuberculoid patient cells released O2- in amounts similar to that generated by cells from normal controls. In addition, monocytes from patients with a high bacterial index had a lower capacity to generate O2- when compared to cells from healthy individuals.</p>},
  year = {1990},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {58},
  pages = {534-9},
  month = {1990 Sep},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v58n3a11.pdf},
  language = {eng},
}