@article{93713,
  keywords = {CD1, T cell, diagnostics, glycolipids, lipid antigen, mycobacteria, tuberculosis, vaccines},
  author = {James C and Seshadri C},
  title = {T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness".},
  abstract = {<p>Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and their associated functions remain to be definitively established. T cells that respond to mycobacterial peptide antigens exhibit classical features of adaptive immunity and have been well-studied in humans and animal models. Recently, innate-like T cells that recognize lipid and metabolite antigens have also been implicated. Specifically, T cells that recognize mycobacterial glycolipid antigens (mycolipids) have been shown to confer protection to tuberculosis in animal models and share some biological characteristics with adaptive and innate-like T cells. Here, we review the existing data suggesting that mycolipid-specific T cells exist on a spectrum of "innateness," which will influence how they can be leveraged to develop new diagnostics and vaccines for mycobacterial diseases.</p>},
  year = {2020},
  journal = {Frontiers in immunology},
  volume = {11},
  pages = {170},
  month = {01/2020},
  issn = {1664-3224},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026021/pdf/fimmu-11-00170.pdf},
  doi = {10.3389/fimmu.2020.00170},
  language = {eng},
}