@article{9332,
  keywords = {Adolescent, Adult, Aged, Antigen-Antibody Complex, Child, Dermatitis, Atopic, Female, Humans, Immune Complex Diseases, Immunoglobulin E, Immunoglobulin G, leprosy, Lichen Planus, Male, Middle Aged, Psoriasis, Pyoderma, Skin Diseases, Vasculitis, Leukocytoclastic, Cutaneous},
  author = {Fernández Bussy R and Crisci C D and Fiorenza G and Bertoya N},
  title = {Evaluation of circulating immune complexes in cutaneous diseases associated with immune disorders.},
  abstract = {<p>Several skin diseases associated with immune disorders may be related to the formation of circulating immune complexes (CIC) and their skin deposition. Sera from 20 controls and 108 patients, including: 23 psoriasis, 10 lichen planus, 30 atopic eczemas, 32 cases of leprosy, 10 vasculitis and 3 pyoderma gangrenosum were evaluated for the presence of IgG-containing CIC by the microconsumption complement test (MCT). Additionally, the presence of IgE-containing CIC by means of a polyethylene glycol precipitation and radioimmunoassay technique was evaluated in 10 patients with atopic eczema. It was found that 56.5% of psoriatic patients show moderate CIC concentrations, as well as 34% of leprosy patients, with increased levels when bacillus were detected in skin lesions, and in 90% of leukocytoclastic vasculitis. A close relationship between CIC levels and the clinical evolution of skin lesions was demonstrated in patients with pyoderma gangrenosum and lichen planus. IgG-CIC were detected in 33% and IgE-CIC in 30% of patients with atopic eczema, with the presence of both types of CIC in 2 out of 3 cases. The systematic research on CIC presence in some selected skin diseases shows that immune complexes take part, with different degrees of relevance, in the pathogenesis of all the entities.</p>},
  year = {1990},
  journal = {Allergologia et immunopathologia},
  volume = {18},
  pages = {47-52},
  month = {1990 Jan-Feb},
  issn = {0301-0546},
  language = {eng},
}