@article{9296,
  keywords = {Aged, Aged, 80 and over, Clofazimine, Drug Eruptions, Female, Humans, Leprosy, lepromatous, Male, Neuronal Ceroid-Lipofuscinoses, Pigmentation Disorders, Skin},
  author = {Job C K and Yoder L and Jacobson R R and Hastings R C},
  title = {Skin pigmentation from clofazimine therapy in leprosy patients: a reappraisal.},
  abstract = {<p>Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.</p>},
  year = {1990},
  journal = {Journal of the American Academy of Dermatology},
  volume = {23},
  pages = {236-41},
  month = {1990 Aug},
  issn = {0190-9622},
  doi = {10.1016/0190-9622(90)70204-u},
  language = {eng},
}