@article{9258,
  keywords = {Animals, Combined Modality Therapy, Dapsone, Drug Therapy, Combination, Interferon-gamma, leprosy, Mice, Mice, Nude, Recombinant Proteins, Rifampin},
  author = {Banerjee D K and McDermott-Lancaster R D},
  title = {Effect of simultaneous administration of interferon-gamma and chemotherapy against Mycobacterium leprae in experimental infection in nude mice.},
  abstract = {<p>The possibility of synergy between immunotherapy with recombinant interferon-gamma (IFN-gamma) and chemotherapy with rifampin (RMP) and dapsone (DDS) against Mycobacterium leprae was examined in nude mice. IFN-gamma alone failed to show any effect on the growth of M. leprae in the nude mouse foot pad. No synergy was demonstrable between DDS, either at 0.0001% or at 0.001%, and IFN-gamma. A subinhibitory level of RMP with IFN-gamma was also ineffective, but RMP at 0.006% with IFN-gamma produced a statistically significant enhancement of killing (26-fold) when compared with RMP at 0.006% only. It should be emphasized, however, that results obtained in the immunodeficient nude mouse model may not be comparable to those which might have been given by lepromatous leprosy patients.</p>
},
  year = {1990},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {58},
  pages = {690-6},
  month = {1990 Dec},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v58n4a07.pdf},
  language = {eng},
}