@article{899,
  keywords = {Adolescent, Adult, Aged, Clofazimine, Dapsone, Drug Administration Schedule, Drug Interactions, Drug Therapy, Combination, Female, Half-Life, Humans, leprosy, Male, Middle Aged, Nigeria, Patient Compliance, Rifampin},
  author = {Pieters F A and Woonink F and Zuidema J},
  title = {Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria.},
  abstract = {<p>In leprosy patients in Nigeria the influence of daily clofazimine and of once-monthly rifampicin on the pharmacokinetics of dapsone has been investigated. Three days after rifampicin the elimination half-life of dapsone was reduced from 40.4 to 25.3 h (n = 23). Correspondingly, the plasma dapsone 24 h after the last dose had fallen significantly from 2.63 to 2.02 mg/l. Clofazimine did not cause change in the pharmacokinetics of dapsone. It was concluded that, although rifampicin had a considerable influence on the pharmacokinetics of dapsone, there is no reason to adjust the dose of dapsone during multidrug therapy of leprosy.</p>},
  year = {1988},
  journal = {European journal of clinical pharmacology},
  volume = {34},
  pages = {73-6},
  month = {1988},
  issn = {0031-6970},
  doi = {10.1007/bf01061421},
  language = {eng},
}